Donor Egg IVF
Bay IVF - Advanced Reproductive Care                                Palo Alto  650-322-0500

 

Prerequisites for Donor Egg IVF

There are very few prerequisites before your treatment can start.

  • Lifestyle and reproductive health

    Environmental factors have a significant impact on reproductive health. Please review Lifestyle and Reproductive Health page, Reproductive Health Check-off Form, and Egg Donor Reproductive Health Check-off Form for a complete list of environmental reproductive health requirements and a source for dietary supplements.

  • Female partner's age

    Pregnancy complications increase significantly with age and could compromise the mother’s and baby’s health. You must be 48 and 11 months or younger at the time your treatment begins. If you are between the ages of 44 and 48, we will need a letter from your OB/GYN, internist, or your family physician stating that it is medically safe for you to become pregnant.

  • Select your egg donor

    The egg donor can be a relative, a friend, or you may wish to find an egg donor through an egg donor agency. Egg donor agencies have a number of pre-selected egg donors for you to choose from.

    Most Donor Egg IVF treatments are anonymous, as it is not medically necessary to meet the egg donor. The donor you select will become a patient at Bay IVF.

    If your egg donor lives outside of the San Francisco Bay Area, please see Out of Area Patients for additional important information.

  • Pathogen testing

    This testing is required by the State of California and FDA. You, your partner, and the egg donor must be tested for several pathogens.

    Recipient partners: Hepatitis B-Surface Antigen, Hepatitis C-Antibody, HIV I&II, HTLV I&II, RPR, and possibly Cytomegalovirus (CMV) if your egg donor is known to be positive for CMV.

    The blood for these tests should be drawn as soon as possible and no later than the egg donor’s menstrual period at the beginning of your treatment. You can go to a laboratory of your choice, or we can draw your blood at our center.

    If you have had any of these tests done within the last 12 months, they do not need to be repeated.

    Egg donor: Hepatitis B-Surface Antigen, Hepatitis B-Core Antibody IgG, Hepatitis B-Core Antibody IgM, Hepatitis C-Antibody, HIV I&II, HTLV I&II, RPR, Chlamydia, and Gonorrhea. The blood for these tests will be drawn at our center.

  • Ovarian Reserve Assay (egg donor)

    ORA assesses the likelihood that normal quality eggs can be produced. It consists of the measurement of Follicle Stimulating Hormone (FSH), estradiol (estrogen, E2), and Anti-Mullerian Hormone (AMH) blood levels. Your egg donor must complete this assay before your treatment begins.

    FSH stimulates the ovaries to produce eggs. If the ovaries cannot produce normal quality eggs, the FSH level is increased. Estradiol production by the ovaries influences FSH secretion and is also related to the egg quality. FSH should ideally be less than 7.0 and estradiol less than 30.

    Interpretation of ORA results depends on the number of antral follicles, seen as small dark circles within each ovary, during your donor's initial ultrasound examination at Bay IVF.

    The number of antral follicles is related to the quality of the eggs. Ideally, there should be approximately 20 antral follicles in both ovaries combined. The majority of women will have 12 to 24 antral follicles.

 

Number of antral follicles in both ovaries combined:
4 to 9

 

  FSH
10.0 or Lower
FSH
10.1 to 11.0
FSH
11.1 or Higher
E2
50 or Lower
OK OK X
E2
51 to 75
OK X X
E2
76 or Higher
X X X

 

Your donor’s treatment can start if:

  1. Her FSH level is 10.0 or less, and estrogen level is 75 or less.
  2. Her FSH is 11.0 or less, and estrogen level is 50 or less.

 

 

Number of antral follicles in both ovaries combined:
10 to 20

 

  FSH
11.0 or Lower
FSH
11.1 to 12.0
FSH
12.1 or Higher
E2
50 or Lower
OK OK X
E2
51 to 75
OK X X
E2
76 or Higher
X X X

 

Your donor’s treatment can start if:

  1. Her FSH level is 11.0 or less, and estrogen level is 75 or less.
  2. Her FSH is 12.0 or less, and estrogen level is 50 or less.

 

 

Number of antral follicles in both ovaries combined:
21 to 30

 

  FSH
11.0 or Lower
FSH
11.1 to 12.0
FSH
12.1 or Higher
E2
50 or Lower
OK OK X
E2
51 to 90
OK X X
E2
91 or Higher
X X X

 

Your donor’s treatment can start if:

  1. Her FSH level is 11.0 or less, and estrogen level is 90 or less.
  2. Her FSH is 12.0 or less, and estrogen level is 50 or less.

 

 

Number of antral follicles in both ovaries combined:
31 or greater

 

  FSH
10.0 or Lower
FSH
10.1 or Higher
E2
Any Level
OK X

 

Your donor's treatment can start if her FSH level is 10.0 or less.

 

AMH level also reflects the quality of eggs; the result should ideally be between 2 and 3. Lower or substantially higher levels signify less than optimal egg quality. AMH result is used to optimize your donor’s ovarian stimulation.

Most egg donors will have normal ORA results. An abnormal result does not necessarily mean that you cannot get pregnant with her eggs. We typically recommend repeating the test.

Out of San Francisco Bay Area donors: If your donor’s AMH result is 5.0 or higher, or her initial visit ovarian ultrasound shows a total of 25 or more follicles within both ovaries, there is a risk of severe ovarian hyperstimulation. Since the symptoms of ovarian hyperstimulation peak seven to ten days after egg retrieval, over which period she may require several immediate visits to our clinic, it would be unsafe for her to be a patient at Bay IVF. See also Out of Area Patients.

  • Measurement of the uterus (recipient mother)

    It is important to place embryo(s) 15 MM below the top of the endometrial cavity. A thin embryo transfer catheter is passed through the cervical canal to the top of the uterus to measure the length of the endometrial cavity.

  • Sonohysterogram (recipient mother)

    We perform a sonohysterogram (saline ultrasound) to assess the endometrial cavity of your uterus. A thin, soft catheter is passed through the cervix into the uterus, and a small amount of sterile saline solution is instilled. A transvaginal ultrasound is used to visualize the contours of the endometrial cavity.

    The presence of polyps, fibroids, or scarring inside the uterus can significantly reduce the probability of implantation. If any polyps, fibroids, or scarring are found, their removal would require a simple outpatient procedure by your OB/GYN or a specialist.

    This ultrasound image shows a normal endometrial cavity. Polyps and fibroids (myomas) would show as lighter shade "filling defects" within the dark saline-filled endometrial cavity.

Sonohysterogram

 

  • Semen evaluation

    The male partner will have a semen evaluation at Bay IVF to determine the best laboratory method for future semen preparation. This test should be done prior to or at your initial Bay IVF visit and needs to be scheduled no later than the donor’s Ovarian Reserve Assay.

    There should be a minimum of 2 days and a maximum of 7 days of sexual abstinence prior to collection. The specimen must be obtained by masturbation.

    If you plan to collect outside of Bay IVF, the specimen must be delivered to Bay IVF Laboratory within one hour of collection. Please make sure you have a Bay IVF Laboratory sterile semen container.

  • Genetic testing

    All potential egg donors are genetically screened for over 100 genetic diseases.

    The male partner should consider genetic screening. Please let us know at the time of your initial appointment at Bay IVF if you wish to have your blood sample sent for genetic screening.

  • Psychological counseling (required for donors)

    Egg donors that are referred by an egg donor agency will have a psychological evaluation in their medical records. If the donor is not referred by an egg donor agency, she will need to have a psychological evaluation. If applicable, her partner may also attend the session.

    If the egg donor is related to the recipient mother, she and the recipient couple will need to have a psychological consultation.

Please use the following links for additional information about Donor Egg IVF.

 

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or a Consultation
with Dr. Polansky

 

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