COVID Vaccine and Pregnancy
Adapted from the "American Society for Reproductive Medicine (ASRM) Position on COVID Vaccine Use in Pregnant Women", issued on January 27, 2021.
Currently available mRNA-based COVID-19 vaccines from Pfizer-BioNTech and Moderna have documented safety and efficacy, preventing up to 95% of severe disease. The known and potential benefits of these vaccines outweigh the known and potential harms of COVID-19 infection.
The ASRM recommends that patients undergoing fertility treatment, pregnant women, and breastfeeding women be vaccinated to minimize risks to themselves and their pregnancy.
The vaccine is taken up rapidly by muscle cells at the injection site, and the mRNA is degraded in the cell once the protein is made, so it does not cross the placenta.
Because COVID-19 mRNA vaccines are not composed of live viruses, they are not thought to cause an increased risk of infertility, first or second-trimester loss, stillbirth, or congenital anomalies.
Patients who conceive in the window between the first and second dose of the vaccine should be offered the second dose of the vaccine at the appropriate interval.