IVF and Immunology

In an effort to improve outcomes of In Vitro Fertilization in general and in patients with recurrent implantation failure and/or pregnancy loss, adjuvant immunotherapies have been introduced into IVF treatment cycles. The rationale behind using these therapies is that they may correct an immunological imbalance resulting in improved and sustained implantation of the developing embryo, ultimately leading to an improved live-birth outcome.

Unfortunately, many immunotherapies lack robust evidence from well-designed controlled trials to support their use. The reviewed immunotherapies are either not associated with improved live-birth outcomes in IVF or have been insufficiently studied.

Summary:

There is good evidence to recommend against the routine use of low-dose aspirin to improve the outcome of live birth in IVF.
There is good evidence to recommend against the routine use of corticosteroids to improve the outcome of live birth in IVF.
There is insufficient evidence to recommend Intravenous Immunoglobulin (IVIG) administration as part of IVF to improve IVF outcomes.
There is insufficient evidence to recommend an intrauterine infusion of autologous peripheral mononuclear cells before embryo transfer to improve IVF outcomes.
There is insufficient evidence to recommend immunosuppressive drug treatment to improve IVF outcomes.

Recommendations:

Immunotherapies are either not associated with improved live-birth outcomes in IVF or have been insufficiently studied to make definitive conclusions regarding benefits and risks.
There is no evidence to suggest screening for immunological conditions in an asymptomatic population considering IVF treatment.

Conclusion:
Immunotherapies aimed at improving the likelihood of live birth in IVF treatment have largely proven to be ineffective or have been insufficiently investigated to make definitive recommendations for their use.

Meet Your Doctor

Dr. Polansky received his medical diploma from Charles University in Prague, the Czech Republic, in 1978.
After completing his OB/GYN residency at Jewish Hospital in Saint Louis, MO, he graduated from the Reproductive Endocrinology and Infertility (REI) fellowship at Stanford University in 1985.
In the same year, he co-founded the Stanford IVF Clinic.
Dr. Polansky obtained board certification in Obstetrics and Gynecology in 1986 and became REI subspecialty board certified in 1988.
In 1987, he left Stanford University and established Nova IVF.
In 2011, he founded Bay IVF, where he provides advanced fertility treatments with a holistic approach, utilizing state-of-the-art techniques.
Dr. Polansky personally performs ultrasound examinations, egg retrievals, embryo transfers, and ovarian and endometrial stimulations for his patients.
He is deeply committed to his patients and freely shares his cell phone number, ensuring accessibility and availability 24/7.

Frank Polansky, M.D.

Initial Appointment Questions

When you call to schedule your consultation, one of our Front Office Coordinators will ask you a short series of questions regarding your reproductive history.

Your name
Your date of birth
Your height
Your weight
Do you know which treatment you plan to have?
How many times have you been pregnant?
For each of your pregnancies, what was the conception date? (month and year)
What was the outcome?
Were the pregnancies with your current partner?
If known, what is the cause of your infertility?
What is your average cycle length? (number of days between onsets of your periods)
Are you currently taking any medications? If yes, which ones?
Are you allergic to any medications? If yes, which ones?
Your partner’s name (if applicable)
Your partner’s date of birth (if applicable)
What is the length of your relationship with your current partner? (years and months)
When was the last time either of you used any contraception?
Is the male partner currently taking any medications? If yes, which ones?
Is the male partner allergic to any medications? If yes, which ones?
What is the total number of pregnancies the male partner has ever caused?
Has the male partner ever caused a pregnancy without the ICSI (Intracytoplasmic Sperm Injection) procedure?
Has the male partner had a vasectomy or vasectomy reversal?
If available, for each Semen Analysis, please give the date (day, month, and year), volume, concentration (sperm count), percentage of motile sperm, and percentage of morphologically normal sperm.
Have you ever had any treatment for, or problems with, your lungs, heart, blood and blood vessels, breasts, digestive system, genito-urinary system, thyroid disease, diabetes, or neurological disorder? (female partner only)
For each X-ray of your uterus and Fallopian tubes (hysterosalpingogram), laparoscopy, hysteroscopy, or laparotomy, please give the procedure date (day, month, and year) and the findings.
If available, for each FSH, LH, estradiol (estrogen, E2), and AMH (Anti-Mullerian Hormone) test you have had, please give the date of the test (day, month, and year) and the result.
Have you done any intrauterine inseminations (IUI)? If yes, how many?
Have you had ovarian stimulation with injectable medications?
For each IVF treatment you have had, please provide the following information if available: Date (month and year), the dose of medications to stimulate your ovaries, your highest estrogen level, number of ovarian follicles that developed, number of eggs retrieved, whether ICSI was done, number of embryos available, number of embryos transferred, number of embryos frozen, and the treatment outcome.
Have you ever smoked cigarettes? If yes, how many cigarettes a day during the last three months? (Please remember that you must not smoke during your treatment.)

See All

Or Download a PDF

This is Erica

She will be providing you with exceptional support throughout your treatment journey at Bay IVF.

Listen to a typical conversation between Erica and a new patient.

Your name
Your date of birth
Your height
Your weight
Do you know which treatment you plan to have?
How many times have you been pregnant?
For each of your pregnancies, what was the conception date? (month and year)
What was the outcome?
Were the pregnancies with your current partner?
If known, what is the cause of your infertility?
What is your average cycle length? (number of days between onsets of your periods)
Are you currently taking any medications? If yes, which ones?
Are you allergic to any medications? If yes, which ones?
Your partner’s name (if applicable)
Your partner’s date of birth (if applicable)
What is the length of your relationship with your current partner? (years and months)
When was the last time either of you used any contraception?
Is the male partner currently taking any medications? If yes, which ones?
Is the male partner allergic to any medications? If yes, which ones?
What is the total number of pregnancies the male partner has ever caused?
Has the male partner ever caused a pregnancy without the ICSI (Intracytoplasmic Sperm Injection) procedure?
Has the male partner had a vasectomy or vasectomy reversal?
If available, for each Semen Analysis, please give the date (day, month, and year), volume, concentration (sperm count), percentage of motile sperm, and percentage of morphologically normal sperm.
Have you ever had any treatment for, or problems with, your lungs, heart, blood and blood vessels, breasts, digestive system, genito-urinary system, thyroid disease, diabetes, or neurological disorder? (female partner only)
For each X-ray of your uterus and Fallopian tubes (hysterosalpingogram), laparoscopy, hysteroscopy, or laparotomy, please give the procedure date (day, month, and year) and the findings.
If available, for each FSH, LH, estradiol (estrogen, E2), and AMH (Anti-Mullerian Hormone) test you have had, please give the date of the test (day, month, and year) and the result.
Have you done any intrauterine inseminations (IUI)? If yes, how many?
Have you had ovarian stimulation with injectable medications?
For each IVF treatment you have had, please provide the following information if available: Date (month and year), the dose of medications to stimulate your ovaries, your highest estrogen level, number of ovarian follicles that developed, number of eggs retrieved, whether ICSI was done, number of embryos available, number of embryos transferred, number of embryos frozen, and the treatment outcome.
Have you ever smoked cigarettes? If yes, how many cigarettes a day during the last three months? (Please remember that you must not smoke during your treatment.)

See All

Or Download a PDF

This is Nisha

Your invaluable resource for effortlessly managing your appointments at Bay IVF.

Listen to a typical conversation between Nisha and a new patient.

Your Initial Visit at Bay IVF

Attending a new patient appointment at a fertility clinic can be stressful. Our primary objective is to ensure that your initial visit is friendly and relaxing. We encourage you to ask questions at every step of the process.

1 — When You Arrive

You will be welcomed by one of the clinic receptionists. One of our nurses will measure your height and weight and take your blood pressure

2 — Meet Your Doctor

Dr. Polansky will ask you a series of clarifying questions and then provide you with a summary of the factors contributing to your infertility

4 — Exam Room

One of the nurses will escort you to an examination room. Your examination will begin with listening to your lungs and heart

3 — Ask Your Questions

You will then have a discussion with him about the most suitable reproductive treatment(s) for you. During this time, you will have the opportunity to ask any questions you may have

5 — Ultrasound of the Ovaries

The next step is a pelvic ultrasound to examine the uterus and ovaries. This ultrasound will help determine the number of antral follicles present within the ovaries

6 — Financial Part

Following that, you will have a discussion with one of the financial advisors regarding the financial aspects of your treatment, including potential treatment financing options

8 — Support 24/7

If you have any questions after leaving the clinic, please feel free to reach out to us via phone call, text, or email. Open and discreet communication is an integral part of the care we provide at Bay IVF